Chloe Krakauer, PhD, MS

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"I strive to use existing methods and develop novel approaches to extract unbiased information efficiently from electronic health data to increase health and wellness for all. I am particularly passionate about tailoring communication of quantitative results to intended audiences to encourage optimal decision-making."

Chloe Krakauer, PhD, MS

Senior Collaborative Biostatistician, Kaiser Permanente Washington Health Research Institute

Biography

Dr. Krakauer is a collaborative biostatistician whose research interests include decision theory, Bayesian statistics, missing data, selection bias, and quantitative communication. Dr. Krakauer received her PhD in biostatistics from the University of Washington in 2021. Her dissertation spanned 2 statistical fields of study: missing data and decision theory.

In her first project, Dr. Krakauer and Dr. Mauricio Sadinle developed a method to estimate the association between potential health determinants and a health outcome that is subject to missing data, or “missingness.” Under these circumstances, investigators must generally make strong, unverifiable assumptions about the reason for missingness to conduct analyses. By using data on the outcome from sources outside the current study, the novel methodology negates the need to make such strong assumptions.

Her second and third projects, with Dr. Kenneth Rice, used decision theory — or decisions based on explicit relative losses for “incorrect” decisions. Drs. Krakauer and Rice applied decision theory to better interpret the evidential worth of significance tests. This research may be used to justify lowering the typical significance threshold of 0.05 and discourage overinterpretation of p-values that just surpass the current typical significance threshold. They further applied decision theory to reducing the Winner’s Curse — bias incurred for limiting reported research results to those that are statistically significant, as is often the case.

At KPWHRI, Dr. Krakauer is currently a statistician with the Adult Changes in Thought (ACT) study, which aims to find ways to prevent or delay dementia, and the STRIPE study, a pragmatic clinical trial on methods to manage pain.  She has previously contributed to studies and grant proposals on smoking cessation and dental health with Oral Health for Life (OH4L), quality of health care at small practices with Healthy Hearts Northwest (H2N), meningitis vaccination strategies, pharmaceutical pricing, and cancer screening procedures.

Research Interests and Experience

Recent Publications

McClure JB, Heffner JL, Krakauer C, Mun S, Klasnja P, Catz SL Feasibility, Acceptability, and Potential Impact of a Novel mHealth App for Smokers Ambivalent About Quitting: Randomized Pilot Study 2023 Jun 28;11:e46155. doi: 10.2196/46155. Epub 2023-06-28. PubMed

Lee CS, Krakauer C, Su YR, Walker RL, Blazes M, McCurry SM, Bowen JD, McCormick WC, Lee AY, Boyko EJ, O'Hare AM, Larson EB, Crane PK Diabetic Retinopathy and Dementia Association, Beyond Diabetes Severity 2023 May;249:90-98. doi: 10.1016/j.ajo.2022.12.003. Epub 2022-12-10. PubMed

Hughes JP, Williamson BD, Krakauer C, Chau G, Ortiz B, Wakefield J, Hendrix C, Amico KR, Holtz TH, Bekker LG, Grant R Combining information to estimate adherence in studies of pre-exposure prophylaxis for HIV prevention: Application to HPTN 067 2022 Mar 15;41(6):1120-1136. doi: 10.1002/sim.9321. Epub 2022-01-25. PubMed

Coleman KF, Krakauer C, Anderson M, Michaels L, Dorr DA, Fagnan LJ, Hsu C, Parchman ML Improving Quality Improvement Capacity and Clinical Performance in Small Primary Care Practices 2021 Nov;19(6):499-506. doi: 10.1370/afm.2733. PubMed

Shores MM, Walsh TJ, Korpak A, Krakauer C, Forsberg CW, Fox AE, Moore KP, Heckbert SR, Thompson ML, Smith NL, Matsumoto AM Association Between Testosterone Treatment and Risk of Incident Cardiovascular Events Among US Male Veterans With Low Testosterone Levels and Multiple Medical Comorbidities 2021 Sep 7;10(17):e020562. doi: 10.1161/JAHA.120.020562. Epub 2021-08-21. PubMed

Krakauer C, Rice K. Chloe Krakauer and Kenneth Rice’s contribution to the discussion of ‘testing by betting: a strategy for statistical and scientific communication’ by Glenn Shafer. J R Stat Soc Series A. 2021;184:432-478. https://doi.org/10.1111/rssa.12660. PubMed

 

Research

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Digital tool could help people change smoking habits

A mobile application designed to engage smokers who are ambivalent about quitting shows promising results.

Research

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Study evaluates biomarker criteria for Alzheimer’s risk

One-third of people classified as ‘highest risk’ may not develop Alzheimer’s disease, study suggests

Learn About the ACT Study

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Understanding brain aging

For over 30 years, the Adult Changes in Thought (ACT) Study has been advancing our understanding of cognition, aging, and better ways to delay and prevent Alzheimer’s disease and related dementias.